Serum Serotonin as a Potential Diagnostic Marker for Hepatocellular Carcinoma
| Autor: | Ahmed Rabiee, Ola El-Sisi, Mahmoud Abdo, Shereen Abdel Alem, Fatma Mamdouh, Amaal A. Abdelaal, Amel Salem |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Serotonin medicine.medical_specialty Carcinoma Hepatocellular Immunology Early detection Gastroenterology 03 medical and health sciences 0302 clinical medicine Virology Internal medicine Biomarkers Tumor medicine Humans business.industry Liver Neoplasms Diagnostic marker Cell Biology Middle Aged medicine.disease digestive system diseases 030104 developmental biology Case-Control Studies Hepatocellular carcinoma Biomarker (medicine) Female 030211 gastroenterology & hepatology business Alpha-fetoprotein |
| Zdroj: | Journal of Interferon & Cytokine Research. 39:780-785 |
| ISSN: | 1557-7465 1079-9907 |
| DOI: | 10.1089/jir.2019.0088 |
| Popis: | To assess the potential role of serum serotonin level in hepatocellular carcinoma (HCC) diagnosis. A case-control study that involved 100 Egyptian adults. Subjects were divided into 4 groups: Group I: 21 patients with late-stage HCC on top of liver cirrhosis, Group II: 28 patients with early-stage HCC on top of liver cirrhosis, Group III: 26 patients with cirrhosis with no evidence of HCC, and Group IV: 25 healthy age- and sex-matched subjects were as a control group. Serum serotonin level was determined in all recruited subjects using high-performance liquid chromatography-fluorescent detection method. Alpha-fetoprotein had a statistically significant elevation in group I with a median of 1300 ng/L (195-2544 ng/L) compared to groups II and III ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|