Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon
| Autor: | Eliana Vieira Pinto, Daniele Freitas Henriques, Consuelo Silva de Oliveira, Pedro Fernando da Costa Vasconcelos, Alessandra Leal, Alana W. de Souza, Vivianne de Paula Reis Guimarães, Juliana Abreu Lima, Luna Thais Souza Gomes, Ana Yecê das Neves Pinto, Priscila Nathyelly dos Santos Graim, Francisco Lúzio de Paula Ramos, Haroldo José de Matos, Ana Cecília Ribeiro Cruz, Emilene Monteiro Furtado Serra, Maura Anjos |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Microcephaly lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 Microcefalia / gen?tica lcsh:Medicine Yellow fever vaccine zika virus infection Zika virus Miscarriage medicine Complica??es na Gravidez microcephaly Original Research Pregnancy biology pregnancy complications Obstetrics business.industry Brasil lcsh:Public aspects of medicine Incidence (epidemiology) lcsh:R Public Health Environmental and Occupational Health lcsh:RA1-1270 medicine.disease biology.organism_classification Zika virus / patogenicidade infectious brazil complicaciones infecciosas del embarazo Infec??o por Zika virus Cohort Infección por el virus Zika Gestation Gravidez business microcefalia medicine.drug |
| Zdroj: | Repositório Digital do Instituto Evandro Chagas (Patuá) Instituto Evandro Chagas (IEC) instacron:IEC Revista Panamericana de Salud Pública, Vol 44, Iss 116, Pp 1-5 (2020) Revista Panamericana de Salud Pública |
| Popis: | Financial support provided by the Evandro Chagas Institute. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Universidade do Estado do Par?. Bel?m, PA, Brazil. Universidade do Estado do Par?. Bel?m, PA, Brazil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Objective. To establish the risk of microcephaly in neonates born to women infected with ZIKV during pregnancy. Methods. A cohort of laboratory-confirmed ZIKV cases of congenital infections (109 mothers infected during pregnancy and 101 newborns) among 308 suspect cases was followed in Belem, Par?, Brazil, from October 2015 to December 2017. Results. A microcephaly risk of 1.98% (95% CI 0.54-6.93%) was found, or 2 cases among the 101 neonates infected with ZIKV during pregnancy. 72% of the pregnant women had ZIKV infection confirmed by RT-qPCR during gestation. Conclusions. Results showed a low incidence of ZIKV-associated birth defects, stillbirth, and miscarriage, which contrasts with previous studies in other Brazilian regions. Previous exposure to yellow fever vaccine and/ or multiserotype DENV infection could be implicated in the protection from ZIKV congenital infection. |
| Databáze: | OpenAIRE |
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