A new model of embolic stroke produced by photochemical injury to the carotid artery in the rat
| Autor: | C. Millikan, N. Futrell, Brant D. Watson, Myron D. Ginsberg, Ricardo Prado, W. Dalton Dietrich |
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| Rok vydání: | 1988 |
| Předmět: |
Male
Pathology medicine.medical_specialty Platelet Aggregation Endothelium Thalamus Hippocampus Photochemistry Lesion Arteriole medicine.artery medicine Animals Platelet Carotid Artery Thrombosis cardiovascular diseases Common carotid artery business.industry Cerebral infarction Rats Inbred Strains Cerebral Infarction Intracranial Embolism and Thrombosis medicine.disease Rats Disease Models Animal Carotid Arteries medicine.anatomical_structure Neurology Microscopy Electron Scanning cardiovascular system Endothelium Vascular Neurology (clinical) medicine.symptom business |
| Zdroj: | Annals of Neurology. 23:251-257 |
| ISSN: | 1531-8249 0364-5134 |
| DOI: | 10.1002/ana.410230307 |
| Popis: | We report a new model of embolic stroke in the rat, based on endothelial disruption and platelet aggregation in the carotid artery, which leads to distal embolization and focal brain infarction. The common carotid artery was irradiated for 6.5 minutes with the focused beam of an argon laser operated at a wavelength of 514.5 nm with a peak power of 2 W and an average power of 400 mw. Ipsilateral cerebral infarcts, ranging in size from 0.1 to 1.7 mm, were produced by platelet emboli in 12 of 13 rats. A total of 44 infarcts were observed in the 12 rats: 29 in the cortex, 6 in the hippocampus, 5 in the thalamus, and 4 in the basal ganglia. Scanning electron microscopy identified platelet aggregates in the carotid artery and in a deep cortical arteriole 50 minutes after the photochemical lesion. Twenty-four hours after the experiment, scanning electron microscopy of the carotid artery revealed damaged endothelium but few remaining adherent platelets. More intense laser irradiation in 8 rats, leading to carotid occlusion, produced an infarct in only 1. This new model can be used to study the acute and chronic pathological changes in the brain associated with platelet embolism. |
| Databáze: | OpenAIRE |
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