Preparation, spectroscopic, characterizations and biological studies of new charge transfer complexes formed between fluconazole drug with various acceptors
| Autor: | Mohamed Ali, Said M. Teleb, Mahmoud M. A. Ali, Akmal S. Gaballa, Sabry A. El-Korashy |
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| Rok vydání: | 2021 |
| Předmět: |
Antifungal Agents
Oscillator strength Transition dipole moment Electron donor Tetracyanoethylene Biochemistry Antioxidants chemistry.chemical_compound Anti-Infective Agents Drug Discovery Humans Fluconazole Molecular Biology chemistry.chemical_classification Bacteria Chemistry Organic Chemistry Fungi Bacterial Infections Electron acceptor Anti-Bacterial Agents Mycoses Stability constants of complexes Proton NMR Physical chemistry Ionization energy |
| Zdroj: | Bioorganic Chemistry. 115:105190 |
| ISSN: | 0045-2068 |
| DOI: | 10.1016/j.bioorg.2021.105190 |
| Popis: | Charge transfer complexes developed during the interaction of Fluconazole drug (FLU) as an electron donor with different types of electron acceptors, including σ-type as iodine (I2), and π-types as 2,3-dinitrosalsylic acid (HDNS), Tetracyanoethylene (TCNE) and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). The formed complexes were characterized using various techniques as UV–Vis spectra, Thermal analyses, spectrophotometric measurements, 1H NMR and FTIR Spectroscopy. It was found that the stoichiometry of all developed complexes was a 1:1 M ratio between fluconazole and acceptors (I2, HDNS, TCNE and DDQ). The characteristic physical parameters data such as ionization potential (ID), The oscillator strength (ƒ), formation constant (KCT), transition dipole moment (μ), free energy (ΔG), and energy of interaction (ECT) of the formed CT-complexes have also been reported. Eventually, the synthesized complexes were screened for their microbial and antioxidant activities. |
| Databáze: | OpenAIRE |
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