Modulation of host cell processes by T3SS effectors
| Autor: | Philippa J. Goddard, R. Christopher D. Furniss, Abigail Clements, Avinash R. Shenoy |
|---|---|
| Přispěvatelé: | Frankel, G, Ron, EZ, Medical Research Council (MRC) |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
030106 microbiology Immunology NF-KAPPA-B Virulence Context (language use) Biology medicine.disease_cause ENTEROPATHOGENIC ESCHERICHIA-COLI Microbiology ACTIN PEDESTAL FORMATION Type three secretion system NLRP3 INFLAMMASOME GTP Phosphohydrolases SIGNALING PATHWAYS 03 medical and health sciences Enteropathogenic Escherichia coli 1108 Medical Microbiology medicine Type III Secretion Systems Humans Escherichia coli Escherichia coli Infections Innate immune system Science & Technology Effector CITROBACTER-RODENTIUM Escherichia coli Proteins INNATE IMMUNE DETECTION biochemical phenomena metabolism and nutrition Actin cytoskeleton III SECRETED EFFECTOR Immunity Innate Cell biology Actin Cytoskeleton Infectious Diseases SMALL GTPASES 1107 Immunology Host-Pathogen Interactions bacteria Signal transduction BACTERIAL EFFECTOR Life Sciences & Biomedicine 0605 Microbiology |
| Zdroj: | Current Topics in Microbiology and Immunology ISBN: 9783319996639 |
| Popis: | Two of the enteric Escherichia coli pathotypes—enteropathogenic E. coli (EPEC) and enterohaemorrhagic E. coli (EHEC)—have a conserved type 3 secretion system which is essential for virulence. The T3SS is used to translocate between 25 and 50 bacterial proteins directly into the host cytosol where they manipulate a variety of host cell processes to establish a successful infection. In this chapter, we discuss effectors from EPEC/EHEC in the context of the host proteins and processes that they target—the actin cytoskeleton, small guanosine triphosphatases and innate immune signalling pathways that regulate inflammation and cell death. Many of these translocated proteins have been extensively characterised, which has helped obtain insights into the mechanisms of pathogenesis of these bacteria and also understand the host pathways they target in more detail. With increasing knowledge of the positive and negative regulation of host signalling pathways by different effectors, a future challenge is to investigate how the specific effector repertoire of each strain cooperates over the course of an infection. |
| Databáze: | OpenAIRE |
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