Inverse Association Between Height-Increasing Alleles and Extreme Longevity in Japanese Women
| Autor: | Mitsuru Higuchi, Yu Taniguchi, Yoshinori Fujiwara, Hiroyuki Suzuki, Nobuyoshi Hirose, Yasumichi Arai, Masaaki Muramatsu, Masashi Tanaka, Motoji Sawabe, Shuichi Obuchi, Tomio Arai, Motonaga Kojima, Hisashi Kawai, Hirohiko Hirano, Hiroshi Shimokata, Noriko Sato, Yoshiji Yamada, Kumpei Tanisawa, Shoji Shinkai, Seijiro Mori, Kazushige Ihara, Maki Sugaya |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Aging medicine.medical_specialty Inverse Association Genotype media_common.quotation_subject medicine.medical_treatment Longevity Single-nucleotide polymorphism Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Japan Internal medicine Medicine Humans Longitudinal Studies Allele Alleles media_common Aged Aged 80 and over business.industry Insulin Odds ratio Middle Aged Genetic architecture Body Height 030104 developmental biology Endocrinology 030220 oncology & carcinogenesis Case-Control Studies Female Geriatrics and Gerontology Centenarian business |
| Zdroj: | The journals of gerontology. Series A, Biological sciences and medical sciences. 73(5) |
| ISSN: | 1758-535X |
| Popis: | Growth hormone (GH)/insulin-like growth factor-1 (IGF-1)/insulin signaling is one of the most plausible biological pathways regulating aging and longevity. Previous studies have demonstrated that several single nucleotide polymorphisms (SNPs) in the GH/IGF-1/insulin signaling-associated genes influence both longevity and adult height, suggesting the possibility of a shared genetic architecture between longevity and height. We therefore examined the relationship between 30 height-associated SNPs and extreme longevity in a Japanese population consisting of 428 centenarians and 4,026 younger controls. We confirmed that height-increasing genetic scores (HGSs) constructed based on 30 SNPs were significantly associated with height in the controls (p = 6.95 × 10-23). HGS was significantly and inversely associated with extreme longevity in women (p = .011), but not in men, although no SNPs were significantly associated with extreme longevity after Bonferroni correction. The odds ratio for extreme longevity in the lowest HGS group (≤27) and the second lowest HGS group (28-30) relative to the highest HGS group (≥37) was 1.71 (p = .056) and 1.69 (p = .034), respectively, for women. In conclusion, the present study demonstrated an inverse association between height-increasing alleles with extreme longevity in Japanese women, providing novel insight into the genetic architecture of longevity and aging. |
| Databáze: | OpenAIRE |
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