| Autor: |
Todd C. Villines, Andrew D. Choi, James K. Min, Tami R. Crabtree, Robert S. Jennings, Marco Guglielmo, Mouaz H. Al-Mallah, Daniele Andreini, Gianluca Pontone, Guus A. de Waard, Paul Knaapen, Philippe Généreux, Erick Avelar, Chris Rowan, Michael Ridner, James J. Jang, Randall C. Thompson, Michiel J. Bom, Roel S. Driessen, U. Joseph Schoepf, Ryo Nakazato, Faisal Nabi, Yang Gao, Bin Lu, Muhammad Akram Khan, Alessia Gimelli, Jason Cole, Sang-Hoon Shin, Hyung-Bok Park, Chang-Wook Nam, Bon-Kwon Koo, Ae-Young Her, Joon-Hyung Doh, Jung Hyun Choi, Hyuk-Jae Chang, Richard J. Katz, Hugo Marques, James P. Earls, Rebecca A. Jonas |
| Rok vydání: |
2022 |
| DOI: |
10.2337/figshare.21341007 |
| Popis: |
Objectives: This study evaluates the relationship between atherosclerotic plaque characteristics (APCs) and angiographic stenosis severity in patients with and without diabetes. Background: Whether APCs differ based on lesion severity and diabetic status is unknown. Methods: We retrospectively evaluated 303 subjects from the CREDENCE trial referred for invasive coronary angiography with coronary computed tomographic angiography (CCTA) and classified lesions as obstructive (>50% stenosed) or non-obstructive using blinded core laboratory analysis of quantitative coronary angiography. CCTA quantified APCs including plaque volume (PV), calcified plaque (CP), noncalcified plaque (NCP), low density noncalcified plaque (LD-NCP), lesion length, positive remodeling (PR), high-risk plaque (HRP) and percent atheroma volume (PAV; plaque volume normalized for vessel volume). The relationship between APCs, stenosis severity and diabetic status was assessed. Results: Among the 303 patients, 95 (31.4%) had diabetes. There were 117 lesions in the diabetic cohort, 58.1% of which were obstructive. Patients with diabetes had greater plaque burden (p=0.004). Patients with diabetes and nonobstructive disease had greater PV (p=0.02), PAV (p=0.02), NCP (p=0.03), PAV NCP (p=0.02), diseased vessels (p=0.03), and max stenosis (p=0.02) than nondiabetic patients with nonobstructive disease. APCs were similar between diabetics with non-obstructive disease and non-diabetic patients with obstructive disease. Diabetic status did not affect HRP or PR. Patients with diabetes had similar APCs in obstructive and non-obstructive lesions. Conclusions: Patients with diabetes and non-obstructive stenosis had an association to similar APCs as patients without diabetes who have obstructive stenosis. Among patients with non-obstructive disease, patients with diabetes had more total PV and NCP. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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