Inositol monophosphatase activity in brain and lymphocyte-derived cell lines of bipolar patients
| Autor: | Galit Shaltiel, Robert H. Belmaker, Boris Nemets, L. Nemanov, Yuri Yaroslavsky, Galila Agam, Richard P. Ebstein, Alon Shamir |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Lymphocyte Cell Culture Techniques Inositol monophosphatase Enzyme-Linked Immunosorbent Assay Inorganic phosphate Internal medicine mental disorders medicine Humans Bipolar disorder Lymphocytes Biological Psychiatry Aged biology Postmortem brain Chemistry Brain Middle Aged medicine.disease Phosphoric Monoester Hydrolases Frontal Lobe Psychiatry and Mental health Endocrinology medicine.anatomical_structure Biochemistry Cell culture Spectrophotometry biology.protein Female Occipital Lobe |
| Zdroj: | The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 2(2) |
| ISSN: | 1562-2975 |
| Popis: | Background: Inositol monophosphatase (IMPase) activity was reported to be low in lymphocyte-derived cell lines of bipolar patients.Methods: IMPase activity was measured spectrophotometrically as inorganic phosphate liberated from inositol-1-phosphate.Results: The previously reported reduction was replicated in a new, small group of bipolar patients. The reduction is not present in cell lines of unipolar or schizophrenic patients. IMPase activity in postmortem frontal and occipital cortical samples of unipolar, bipolar and schizophrenic patients was not different from controls.Conclusions: A reduction in lymphocyte-derived IMPase activity without a parallel reduction in cortical IMPase activity could be due to the fact that most leukocyte IMPase activity is the product of the IMPA-2 gene. |
| Databáze: | OpenAIRE |
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