| Autor: |
Tania, Siahanidou, Helen, Mandyla, Stavros, Doudounakis, Dimitris, Anagnostakis |
| Rok vydání: |
2005 |
| Předmět: |
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| Zdroj: |
Acta Paediatrica. 94:1837-1840 |
| ISSN: |
0803-5253 |
| DOI: |
10.1080/08035250510040241 |
| Popis: |
Abnormal glucose tolerance is a frequent late complication of cystic fibrosis (CF), but the prevalence of CF-related diabetes mellitus (CFRD) in children less than 10 y old is less than 2%. The youngest child with CFRD reported to date was 6 mo of age. Insulinopenia is the primary cause of abnormal glucose tolerance/CFRD, but it is unknown whether it may begin in the neonatal period. We describe a case of a neonate with CF who presented with hyperglycaemia in the diabetic range and marked insulinopenia. Insulinopenia and impaired glucose tolerance were permanent findings at 6 and 15 mo of age.This case suggests that abnormal glucose tolerance/diabetes may occur much earlier in the course of CF, even during neonatal age. Careful follow-up and further studies in CF infants could reveal that the real incidence of glucose intolerance and diabetes in this age group has been underestimated. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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