Correlation between Nitric Oxide Synthesis and Histamine Release in Mast Cells from Spontaneously Hypertensive Rats: Influence of Aging
| Autor: | P. F. Mannaioni, E. Gambassi, M. Lupini, Alessandra Pistelli, Emanuela Masini |
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| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Nitric oxide synthesis Immunology Ionophore chemistry.chemical_element General Medicine Calcium Mast cell Nitric oxide chemistry.chemical_compound Endocrinology medicine.anatomical_structure Biosynthesis chemistry Internal medicine medicine Immunology and Allergy Liberation Histamine |
| Zdroj: | International Archives of Allergy and Immunology. 99:404-407 |
| ISSN: | 1423-0097 1018-2438 |
| DOI: | 10.1159/000236297 |
| Popis: | Isolated perfused hearts and serosal mast cells (MC) of 2- 6- and 18-month-old spontaneously hypertensive rats (SH) were compared to hearts and MC from Wistar-Kyoto (WKY) rats of the same age for their ability to release nitric oxide (NO). The relationship between histamine release and NO production was also investigated. In hearts and MC of 2-, 6- and 18-month-old SH rats, the production of NO is significantly lower than in hearts or MC of WKY rats of the same age. Concomitantly, the spontaneous release of histamine in cardiac perfusates and MC reactivity to various exocytotic stimuli (compound 48/80, calcium ionophore A 23187) is modified by aging and hypertension. |
| Databáze: | OpenAIRE |
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