HLA-G*01:04∼UTR3 Recipient Correlates With Lower Survival and Higher Frequency of Chronic Rejection After Lung Transplantation
| Autor: | Philippe Thomas, J. Di Cristofaro, Martine Reynaud-Gaubert, Federico Carlini, Agnès Basire, Carine Gomez, Christian Picard, Anderson Loundou, Coralie Frassati, Pierre L. Roubertoux |
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| Přispěvatelé: | Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), Etablissement Français du Sang - Alpes-Méditerranée (EFS - Alpes-Méditerranée), Etablissement Français du Sang, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Plasticité et physio-pathologie de la motricité (P3M) (PPPMP), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Service de chirurgie thoracique, Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Assistance Publique - Hôpitaux de Marseille (APHM), INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de la Méditerranée - Aix-Marseille 2, Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital nord, Dubois Frid, Caroline |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Graft Rejection Lung Diseases Male medicine.medical_specialty [SDV.IMM] Life Sciences [q-bio]/Immunology medicine.medical_treatment Single-nucleotide polymorphism Human leukocyte antigen Cystic fibrosis Gastroenterology Polymorphism Single Nucleotide Postoperative Complications Risk Factors Internal medicine HLA-G medicine Immunology and Allergy Lung transplantation Humans Pharmacology (medical) Allele 3' Untranslated Regions ComputingMilieux_MISCELLANEOUS Retrospective Studies HLA-G Antigens Transplantation business.industry Haplotype Graft Survival Retrospective cohort study medicine.disease Prognosis 3. Good health Survival Rate Haplotypes Immunology Chronic Disease [SDV.IMM]Life Sciences [q-bio]/Immunology Female business Follow-Up Studies Lung Transplantation |
| Zdroj: | American Journal of Transplantation American Journal of Transplantation, 2015, pp.2015 May 18 American Journal of Transplantation, Wiley, 2015, pp.2015 May 18 |
| ISSN: | 1600-6135 1600-6143 |
| Popis: | Lung transplantation (LTx) is a valid therapeutic option for selected patients with end-stage lung disease. Soluble HLA-G (sHLA-G) has been associated with increased graft survival and decreased rejection episodes in solid organ transplantation. HLA-G haplotypes named UTRs, defined by SNPs from both the 5′URR and 3′UTR, have been reported to reliably predict sHLA-G level. The aim of this retrospective study was to determine the impact of HLA-G alleles and UTR polymorphism from LTx recipients on anti-HLA allo-immunization risk, overall survival and chronic rejection (CLAD). HLA-G SNPs were genotyped in 124 recipients who underwent LTx from 1996 to 2010 in Marseille, 123 healthy individuals and 26 cystic fibrosis patients not requiring LTx. sHLA-G levels were measured for 38 LTx patients at D0, M3 and M12 and for 123 healthy donors. HLA-G*01:06∼UTR2 was associated with a worse evolution of cystic fibrosis (p = 0.005) but not of long-term survival post-LTx. HLA-G*01:04∼UTR3 haplotype was associated with lower levels of sHLA-G at D0 and M3 (p = 0.03), impaired long-term survival (p = 0.001), increased CLAD occurrence (p = 0.03) and the production of de novo donor-specific antibodies (DSA) at M3 (p = 0.01). This study is the first to show the deleterious association of different HLA-G alleles and UTRs in LTx. |
| Databáze: | OpenAIRE |
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