Association of neurologic manifestations and CEA levels with the diagnosis of brain metastases in lung cancer patients
| Autor: | Gervith Reyes-Soto, Bernardo Cacho-Díaz, Laura G. Mendoza-Olivas, Héctor Spínola-Maroño, Oscar Arrieta, Alejandro Monroy-Sosa |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Cancer Research medicine.medical_specialty Lung Neoplasms Comorbidity Logistic regression Gastroenterology Sensitivity and Specificity Serology 03 medical and health sciences Young Adult 0302 clinical medicine Carcinoembryonic antigen Seizures Internal medicine Carcinoma Non-Small-Cell Lung medicine Biomarkers Tumor Humans Prospective Studies Lung cancer Aged Aged 80 and over biology business.industry Brain Neoplasms Headache Cancer General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Carcinoembryonic Antigen 030104 developmental biology Oncology ROC Curve 030220 oncology & carcinogenesis Cohort biology.protein Regression Analysis Female Focal motor weakness business Clinical record |
| Zdroj: | Clinicaltranslational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 21(11) |
| ISSN: | 1699-3055 |
| Popis: | Lung cancer (LC) is the most common source of brain metastases (BM). Because of the difficulty in predicting LC patients who will develop BM, we aimed to identify the clinical and serologic markers that could predict the presence of BM in LC patients. We analyzed a cohort of LC patients sent for neurooncological consultation for any neurologic symptom at a cancer center from June 2013 to July 2017. Inclusion criteria: histologically confirmed LC, age ≥ 18 years and complete clinical records. Exclusion criteria: BM diagnosis before our consultation and absence of MRI. Oncologic history, clinical symptoms and comorbidities were analyzed. From 199 patients, most (70%) had > 1 neurological symptom. The most common was headache (n = 46, 21%), followed by seizures (17%), altered mental status (16%) and focal motor weakness (13%). BM was found in 74% of the patients during follow-up. Multivariate logistic regression analysis showed factors associated with a higher frequency of BM: age |
| Databáze: | OpenAIRE |
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