Pediatric third liver transplantation-A single-center experience
| Autor: | Gordon Thomas, Susan Siew, Albert Shun, Brooke Andersen, Michael R Couper, Michael Stormon, Edward O'Loughlin, Vicki Jermyn, Janine Sawyer |
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| Rok vydání: | 2021 |
| Předmět: |
Graft Rejection
Male Reoperation Pediatrics medicine.medical_specialty Adolescent medicine.medical_treatment Liver transplantation Single Center Sepsis Postoperative Complications Medicine Humans Child Transplantation business.industry Graft Survival Australia Infant Patient survival medicine.disease Prognosis Liver Transplantation surgical procedures operative Child Preschool Pediatrics Perinatology and Child Health Cohort Transplant patient Female business Neurological impairment |
| Zdroj: | Pediatric transplantationREFERENCES. 25(8) |
| ISSN: | 1399-3046 |
| Popis: | Background Pediatric retransplantation is an accepted practice for graft failure and complications in Australasia. As 15% of children require a third transplant, this is a growing cohort with limited data in the literature. Methods We review nine patients from the commencement of our transplantation program in 1986 up to 2020 assessing demographics, prognosis, and outcome measures. Results Third transplant patient survival was comparative to first and second transplant patient survival at 5 years. All deaths were within the post-operative period and secondary to sepsis. Operative times and transfusion volumes were increased at third transplant (1.8 and 4.5 times compared to first transplant, respectively). Learning difficulties and psychological disturbances were prevalent (83% and 66.6%, respectively). Conclusions While recent mortality outcomes appear comparable to undergoing a second liver transplant, third transplant operations were more complex. Neurological impairment and psychological disturbance appear to be prevalent and need to be considered in pre-transplant counseling. |
| Databáze: | OpenAIRE |
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