The value of narrowband imaging using the Ni classification in the diagnosis of laryngeal cancer

Autor:	Mark C. Smith, Niranjan Sritharan, Faruque Riffat, Narinder Singh, Carsten E. Palme, Sejad Ahmadzada, Evan Tseros
Rok vydání:	2020
Předmět:	medicine.medical_specialty narrowband imaging Head and Neck and Tumor Biology lcsh:Surgery NBI glottic cancer Biopsy medicine Advanced disease Ni classification Original Research medicine.diagnostic_test business.industry Cancer Level iv lcsh:RD1-811 General Medicine lcsh:Otorhinolaryngology Severe dysplasia medicine.disease lcsh:RF1-547 Glottic Squamous Cell Carcinoma Glottic cancer White light endoscopy laryngeal cancer Radiology business
Zdroj:	Laryngoscope Investigative Otolaryngology Laryngoscope Investigative Otolaryngology, Vol 5, Iss 4, Pp 665-671 (2020)
ISSN:	2378-8038
DOI:	10.1002/lio2.414
Popis:	Introduction Narrowband imaging (NBI) is a special endoscopic optical enhancement setting allowing better visualization of mucosal microvasculature compared to white light endoscopy. This study evaluates the validity of NBI using the Ni classification in the detection and differentiation of severe dysplasia (SD) and glottic squamous cell carcinoma (SCC). Methods Patients with suspicious vocal cord lesions underwent conventional white light endoscopy followed by clinically indicated biopsy. At the same time, NBI images were obtained and graded independently. Lesions were graded from I to V according to the Ni classification and compared to histopathological findings. Results Fifty‐two patients were included in this study (40 SCC and 12 SD). The sensitivity and specificity of NBI in diagnosing laryngeal cancer was 95.0% (CI, 83.9%‐99.4%) and 83.3% (CI, 51.6%‐97.9%), respectively. The negative likelihood ratio was 0.06. Higher Ni grades correlated very strongly with more advanced disease. Conclusions NBI using the Ni classification is a sensitive diagnostic tool for the detection and differentiation of early neoplastic and preneoplastic glottic lesions. As higher Ni classification correlates strongly with advanced disease, it serves as a useful adjunct to white light endoscopy in the diagnosis of laryngeal cancer. Level of Evidence: Level IV.
Databáze:	OpenAIRE
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