Engineering Gram Selectivity of Mixed-Charge Gold Nanoparticles by Tuning the Balance of Surface Charges
| Autor: | M. Borkowska, Pramod P. Pillai, Bartlomiej Kowalczyk, Kristiana Kandere-Grzybowska, Bartosz A. Grzybowski |
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| Rok vydání: | 2016 |
| Předmět: |
Stereochemistry
Static Electricity Nanoparticle Metal Nanoparticles 02 engineering and technology 010402 general chemistry Gram-Positive Bacteria Ligands 01 natural sciences Catalysis Bacterial cell structure Mice Gram-Negative Bacteria Animals Surface charge Sulfhydryl Compounds Gram Microscopy Confocal Chemistry Ligand Fatty Acids Charge (physics) General Chemistry Drug Tolerance 021001 nanoscience & nanotechnology Combinatorial chemistry 0104 chemical sciences Quaternary Ammonium Compounds Colloidal gold Gold 0210 nano-technology Selectivity |
| Zdroj: | Angewandte Chemie (International ed. in English). 55(30) |
| ISSN: | 1521-3773 |
| Popis: | Nanoparticles covered with ligand shells comprising both positively and negatively charged ligands exhibit Gram-selective antibacterial action controlled by a single experimental parameter, namely the proportion of [+] and [-] ligands tethered onto these particles. Gram selectivity is attributed to the interplay between polyvalent electrostatic and non-covalent interactions that work in unison to disrupt the bacterial cell wall. The [+/-] nanoparticles are effective in low doses, are non-toxic to mammalian cells, and are tolerated well in mice. These results constitute the first example of rational engineering of Gram selectivity at the (macro)molecular level. |
| Databáze: | OpenAIRE |
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