Synthesis and Antimicrobial Activities of Some 1-[(N, N-Disubstitutedthiocarbamoylthio)acetyl]-3,5-diaryl-2-pyrazolines

Autor:	Yağmur Tunalı, Zafer Asım Kaplancıklı, Pierre Chevallet, Guelhan Turan‐Zitouni, Ahmet Oezdemir
Přispěvatelé:	Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Turan, Gülhan, Özdemir, Ahmet, Kaplancıklı, Zafer Asım, Tunalı, Yağmur
Rok vydání:	2005
Předmět:	Chemistry Organic Chemistry Antimicrobial compound Pyrazoline General Medicine Antimicrobial Antimicrobial Activity Combinatorial chemistry Biochemistry Inorganic Chemistry chemistry.chemical_compound Dithiocarbamic Acid Organic chemistry
Zdroj:	Phosphorus, Sulfur, and Silicon and the Related Elements. 180:2717-2724
ISSN:	1563-5325 1042-6507
DOI:	10.1080/104265090930452
Popis:	WOS: 000234212900011 The increasing clinical importance of drug-resistant fungal and bacterial pathogens has lent additional urgency to microbiological research and new antimicrobial compound development. For this put-pose, new pyrazoline derivatives were synthesized and evaluated for antimicrobial activity. Some 1-[(N,N-disubstitutedthiocarbamoylthio)acetyl]-3,5-dialyl-2-pyrazolines derivatives were synthesized by reacting 1-(chloroacetyl)-3,5-diaryl-2-pyrazolines with appropriate potassium salts of secondary amine dithiocarbamic acids. The chemical structures of the compounds were elucidated by IR, H-1-NMR, and FAB(+)-MS spectral data. Their antimicrobial activities against Staphylococcus aureus (B-767), Escherichia coli (B-3704), Pseudomonas aeruginosa (ATCC 27853), Proteus vulgaris (NRLL B-123), and Candida. albicans (NRRL-27077) were investigated. The results showed that some of the compounds have notable activity against S. aureus and C. albicans.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1f96543fb3d4d5bd8c7e3d1cf58838 https://doi.org/10.1080/104265090930452 Zobrazit plný text záznamu