Lower ribavirin biodisponibility in patients with HIV-HCV coinfection in comparison with HCV monoinfected patients
Autor: | Marie-Claude Gagnieu, Patrick Miailhes, Jean-Michel Livrozet, Fabien Zoulim, François Parant, François Bailly, Marianne Maynard, Pierre Chiarello, Giorgiana Hatu, Pierre Pradat, Emmanuel Pourcelot |
---|---|
Přispěvatelé: | Service d'hépatologie, Hospices Civils de Lyon (HCL)-Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL), Université de Médicine et Pharmacie 'Iuliu Hatieganu', Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Pharmacologie, Hospices Civils de Lyon (HCL)-Hôpital Edouard Herriot [CHU - HCL], Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL], Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Service d'immunologie, BMC, Ed., Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
Jazyk: | angličtina |
Rok vydání: | 2014 |
Předmět: |
Male
HIV Infections medicine.disease_cause 030226 pharmacology & pharmacy Gastroenterology chemistry.chemical_compound 0302 clinical medicine Pegylated interferon [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases 0303 health sciences education.field_of_study Human immunodeficiency virus Coinfection Area under the curve virus diseases Hepatitis C Middle Aged 3. Good health Infectious Diseases [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases Female medicine.drug Research Article Adult medicine.medical_specialty Combination therapy Hepatitis C virus Population Biological Availability Antiviral Agents Ribavirin exposure 03 medical and health sciences Young Adult Internal medicine Ribavirin medicine Humans education Aged 030306 microbiology business.industry Hepatitis C Chronic medicine.disease Treatment chemistry Immunology business |
Zdroj: | BMC Infectious Diseases BMC Infectious Diseases, 2014, 14 (1), pp.150. ⟨10.1186/1471-2334-14-150⟩ BMC Infectious Diseases, BioMed Central, 2014, 14 (1), pp.150. ⟨10.1186/1471-2334-14-150⟩ |
ISSN: | 1471-2334 |
Popis: | International audience; BACKGROUND: In HIV infected patients, the impact of ribavirin (RBV) pharmacology on sustained virologic response (SVR) to hepatitis C virus (HCV) treatment has not been fully investigated. The objective of this study was to compare the early RBV plasma exposure between a population of HIV-HCV coinfected patients and an HCV monoinfected group. METHODS: Early RBV plasma exposure (expressed as Area Under the Curve (AUC) from 0 to 4 h) after a 600 mg first dose of RBV was measured in a population of HIV-HCV coinfected patients in comparison with an HCV monoinfected group. Peripheral blood samples were collected before the 600 mg RBV first dose (T0) to ensure no detectable baseline plasma RBV, and then 30 mn, 1, 2 and 4 hours after RBV intake (T0.5, T1, T2 and T4). RESULTS: Eighty-six patients with chronic hepatitis C entered the study among whom 23 (27%) were HIV-HCV coinfected. Coinfected patients had a significantly lower RBV-AUC(0-4h) (median: 1469 μg*h/L [range 936-3677]) compared with monoinfected patients (2030 μg*h/L [851-7700]; p = 0.018). This RBV under exposure in coinfected patients persisted after normalization of AUC to RBV dose per kilogram of body weight (182 μg*h/L [110-425] versus 271 μg*h/L [82-1091], p = 0.001). CONCLUSIONS: These results suggest that lower early bioavailability of RBV could be one of the reasons for lower SVR in HIV-HCV coinfected patients treated with pegylated interferon/RBV combination therapy. RBV plasma underexposure seems to be associated with the immunological status of the patients with lower AUC(0-4h) values observed in the more immunosuppressed coinfected patients. |
Databáze: | OpenAIRE |
Externí odkaz: |