S100B gene polymorphisms predict prefrontal spatial function in both schizophrenia patients and healthy individuals
| Autor: | Chuanxin Liu, Qiumei Zhang, Li Gao, Feng Ji, Keqin Wang, Zhansheng Xu, Jun Li, Qi Dong, Jicheng Dong, Jinguo Zhai, Xiaoxiang Deng, Qiuge Shen, Xiongying Chen, Lina Cheng, Chuansheng Chen, Min Chen |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Genotyping Techniques Spatial ability Single-nucleotide polymorphism S100 Calcium Binding Protein beta Subunit Bioinformatics Polymorphism Single Nucleotide Spatial memory Mental rotation Executive Function Genotype medicine Humans SNP Nerve Growth Factors Psychiatry Biological Psychiatry Working memory S100 Proteins Middle Aged medicine.disease Psychiatry and Mental health Memory Short-Term Schizophrenia Case-Control Studies Space Perception Female Cognition Disorders Psychology |
| Zdroj: | Zhai, J; Cheng, L; Dong, J; Shen, Q; Zhang, Q; Chen, M; et al.(2012). S100B gene polymorphisms predict prefrontal spatial function in both schizophrenia patients and healthy individuals. Schizophrenia Research, 134(1), 89-94. doi: 10.1016/j.schres.2011.09.029. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7fw2m7r2 |
| ISSN: | 0920-9964 |
| Popis: | Animal studies have strongly implicated a role of S100B in spatial ability and our recent study of humans found that S100B gene polymorphisms (rs9722, rs1051169, and rs2839357) were associated with schizophrenia patients' spatial ability (as assessed by a block design task and a mental rotation task). In this study, we explored the associations between these and three additional SNPs in S100B and prefrontal functions (working memory and executive control) among 434 schizophrenia patients and 412 healthy controls. Results showed that, for both schizophrenia patients and healthy controls, two SNPs were significantly associated with prefrontal functions in the spatial domain (P value threshold was set at 0.014 after correcting for multiple comparisons), with the AA genotype of rs9722 and the GG genotype of rs2839357 linked to poorer performance. No SNP was associated with prefontal functions in the verbal domain (all Ps > 0.05). These results extend our previous study and further confirm the important roles of the S100B gene in spatial abilities. © 2011 Elsevier B.V. |
| Databáze: | OpenAIRE |
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