A novel human cDNA highly homologous to the fish hormone stanniocalcin
| Autor: | Miriam Hulsbeek, Andy C.-M. Chang, Jackie B.M. Janosi, Debora de Jong, Jane R. Noble, Katherine J. Jeffrey, Roger R. Reddel |
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| Rok vydání: | 1995 |
| Předmět: |
DNA
Complementary Molecular Sequence Data Gene Expression Sequence Homology Ovary Biology Biochemistry Cell Line Endocrinology Salmon Complementary DNA Extracellular medicine Animals Humans STC1 Amino Acid Sequence RNA Messenger Molecular Biology Glycoproteins chemistry.chemical_classification Messenger RNA Eels Base Sequence Fishes Sequence Analysis DNA Oncorhynchus kisutch Blotting Northern Molecular biology Hormones medicine.anatomical_structure Liver chemistry Oncorhynchus mykiss Calcium Glycoprotein Homeostasis Hormone |
| Zdroj: | Molecular and Cellular Endocrinology. 112:241-247 |
| ISSN: | 0303-7207 |
| DOI: | 10.1016/0303-7207(95)03601-3 |
| Popis: | Stanniocalcin is a glycoprotein hormone previously considered present only in bony fish where it is secreted by the corpuscles of Stannius, endocrine organs involved in Ca2+ homeostasis. In fish, stanniocalcin was thought to be an adaptation for Ca2+ regulation in aquatic environments, and its effects include inhibition of gill Ca2+ transport. We have obtained a human cDNA clone coding for a protein highly homologous to fish stanniocalcin. The mRNA is expressed in many human tissues, with the highest levels in ovary, prostate and thyroid. In vitro human cell culture studies show that the mRNA is positively regulated by extracellular Ca2+ in the medium We conclude that a human protein similar to the fish hormone is expressed in multiple tissues rather than by a specialized endocrine organ. |
| Databáze: | OpenAIRE |
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