Anti-Friction MSCs Delivery System Improves the Therapy for Severe Osteoarthritis
| Autor: | Jia-Kuo Yu, Yuanchen Dong, Dongsheng Liu, Yi-Fan Song, Jing Ye, Fengbiao Mao, You-Rong Chen, Yufan Pan, Xin Yan, Yuqing Wang, Bo Yang, Bini Zhou |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
Friction Mechanical Engineering Cartilage Mesenchymal stem cell technology industry and agriculture macromolecular substances Osteoarthritis medicine.disease Cell delivery Cell therapy medicine.anatomical_structure Mechanics of Materials In vivo Cancer research medicine General Materials Science Delivery system Cell damage |
| Zdroj: | Advanced materials (Deerfield Beach, Fla.). 33(52) |
| ISSN: | 1521-4095 |
| Popis: | Osteoarthritis (OA) is a musculoskeletal disorder disease affecting about 500 million people worldwide and mesenchymal sem cells (MSCs) therapy has been demonstrated as a potential strategy to treat OA. However, the shear forces during direct injection and the harsher shear condition of OA environments would lead to significant cell damage and inhibit the therapeutic efficacy. Herein, DNA supramolecular hydrogel has been applied as delivering material for MSCs to treat severe OA model, which perform extraordinary protection in MSCs against the shear force both in vitro and in vivo. It is demonstrated that the DNA supramolecular hydrogel can promote formation of quality cartilage, reduce osteophyte, and normalize subchondral bone under the high friction condition of OA, whose molecular mechanisms underlying therapeutic effects are also investigated. It can be anticipated that DNA supramolecular hydrogel would be a promising cell delivery system for multiple potential MSCs therapy. |
| Databáze: | OpenAIRE |
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