The impact of age and gender on right ventricular diastolic function among healthy adults
| Autor: | Rodolfo Citro, Antonio Cittadini, Gianluigi Tagliamonte, Enrica Pezzullo, Raffaele Calabrò, Marco Di Maio, Antonello D'Andrea, Olga Vriz, Andreina Carbone, Francesco Ferrara, Eduardo Bossone, Caterina Driussi, Rosangela Cocchia, Edwige Acri, Maria Giovanna Russo |
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| Přispěvatelé: | D'Andrea, Antonello, Vriz, Olga, Carbone, Andreina, Ferrara, Francesco, Di Maio, Marco, Cocchia, Rosangela, Tagliamonte, Gianluigi, Acri, Edwige, Driussi, Caterina, Pezzullo, Enrica, Citro, Rodolfo, Cittadini, Antonio, Calabrò, Raffaele, Giovanna Russo, Maria, Bossone, Eduardo |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Systole Heart Ventricles Diastole 030204 cardiovascular system & hematology Doppler echocardiography Cohort Studies Young Adult 03 medical and health sciences Sex Factors 0302 clinical medicine Reference Values Internal medicine medicine Humans Diastolic function Heart Atria Young adult Aged Aged 80 and over medicine.diagnostic_test E/A ratio business.industry Age Factors Reference range Middle Aged E/e′ medicine.anatomical_structure 030228 respiratory system Echocardiography Ventricle Ventricular Function Right Cardiology Right ventricle Female Cardiology and Cardiovascular Medicine business Cohort study |
| Zdroj: | Journal of Cardiology. 70:387-395 |
| ISSN: | 0914-5087 |
| DOI: | 10.1016/j.jjcc.2016.12.005 |
| Popis: | Background Doppler echocardiography is ideally suited for assessment of diastolic function, being widely available, non-invasive, and less expensive than other techniques. However, data regarding age- and gender-matched reference values of right ventricular diastolic function are limited. This study aims to explore the physiologic variations of right ventricle (RV) diastolic function in a large cohort of healthy adults, and to investigate clinical and echocardiographic correlates. Methods From June 2007 to February 2014, 1168 healthy Caucasian subjects [mean age 45.1 ± 15.6 years, range 16–92; 555 (47.5%) men] underwent comprehensive transthoracic echocardiography (TTE) following current guidelines. The following RV main diastolic measurements were measured: peak early inflow velocity (E), annular both early (e′) and atrial (a′) velocities, E/e′ ratio. Results RV E/e′ constantly increases with age in females, but do not change substantially in males. RV E/A constantly decreases with age in both genders. Stepwise multiple linear regression analysis underlined a close significant association of RV diastolic function with both right and left heart morphologic measurements (right atrial area, RV diameters, left atrial volume) and functional indexes (TAPSE, RV tissue Doppler peak systolic velocity, left ventricular E/Ee′), as well as with indexes of increased pulmonary resistance. Conclusion Our data highlight the potential usefulness of different normal reference values according to the age and gender to correctly evaluate RV diastolic function. Differences in terms of demographic and anthropometric parameters could be useful to avoid potential misclassification of RV diastolic function when based on dichotomously suggested normal cut-off values. |
| Databáze: | OpenAIRE |
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