Comparative Study between the Combination of Dexamethasone and Bupivacaine for Third Molar Surgery Postoperative Pain: A Triple-Blind, Randomized Clinical Trial
| Autor: | María del Mar Requena-Mullor, Damaso Fernández-Ginés, Raquel Alarcón-Rodríguez, Francisco Javier Quesada-Bravo, Ana Rocío García-Carricondo, Carmen Fernández-Sánchez, Fernando Espín-Gálvez |
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| Rok vydání: | 2021 |
| Předmět: |
Bupivacaine
business.industry Visual analogue scale submucosa Analgesic bupivacaine Phases of clinical research dexamethasone General Medicine Articaine Article law.invention Third molar surgery Randomized controlled trial law Anesthesia Medicine business postoperative pain Dexamethasone third molar surgery medicine.drug |
| Zdroj: | riUAL. Repositorio Institucional de la Universidad de Almería Universidad de Almería Journal of Clinical Medicine, Vol 10, Iss 5081, p 5081 (2021) Journal of Clinical Medicine Volume 10 Issue 21 |
| Popis: | Objectives: To compare the possible benefits of the combination of dexamethasone–bupivacaine with articaine–epinephrine as an anaesthetic block after third molar surgery. Materials and Methods: Triple-blind, randomized, controlled, parallel, phase 3 clinical trial. Two groups: experimental (93 patients) with standard anaesthetic block: 40/0.005 mg/mL articaine–epinephrine and submucosal reinforcement with 0.8 mg dexamethasone–5% bupivacaine and control group (91 patients) with standard block: 40/0.005 mg/mL articaine–epinephrine. The surgery consisted of the extraction of the impacted mandibular third molar by performing a procedure following the same repeatable scheme. The visual analogue scale (VAS) was used to analyse postoperative pain. Results: Groups were homogeneous, without significant differences related to epidemiological variables. Postoperative pain among the first, second, and seventh postoperative days was statistically significantly lower in the experimental group compared to the control group (p < 0.001). Drug consumption was lower in the experimental group throughout the study period (p < 0.04). Conclusion: Bupivacaine is an alternative to articaine in oral surgery, being more effective in reducing postoperative pain by reducing patients’ scores on the VAS as well as their consumption of analgesic drugs after surgery. |
| Databáze: | OpenAIRE |
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