| Autor: |
Dingkang Liu, Ye Chen, Qun Wang, Yue Ji, Lichen Bao, Wenbing Yao, Xiangdong Gao, Jun Yin |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of Controlled Release. 346:250-259 |
| ISSN: |
0168-3659 |
| DOI: |
10.1016/j.jconrel.2022.04.022 |
| Popis: |
Multidrug resistance (MDR) to chemotherapeutic drugs and targeted drug delivery are recurring issues in clinical cancer treatment. Here, a multifunctional fusion protein-DNA conjugate was designed as a co-delivery vehicle for anticancer peptides and chemotherapeutic drugs to combat both drug-resistant and drug-sensitive tumor cells. The fusion protein was constructed by fusing a PsTag polypeptide, a matrix metalloproteinase 2 (MMP2)-degradable domain, and the mitochondria-targeted pro-apoptotic peptide KLAKLAKKLAKLAK. Doxorubicin was efficiently loaded into the fusion protein pre-conjugated dendrimer-like DNA nanostructure. With the incorporation of enhanced stability, tumor targeting, and controlled-release elements, the tailored nanostructure can selectively enter tumor cells and synergistically exert antitumor activity with no significant adverse effects. Thus, these protein-conjugated DNA nanocarriers could be a potential co-delivery system for protein/peptide and chemotherapeutic drugs delivery in synergistic cancer therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect