Adiponectin receptor expression in gastric carcinoma: implications in tumor development and progression
| Autor: | Gheeyoung Choe, Hye Seung Lee, Nam Hee Won, Eun Shin, Do Joong Park, Hyung Ho Kim |
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| Rok vydání: | 2012 |
| Předmět: |
Adenoma
Adult Male Cancer Research medicine.medical_specialty Adenocarcinoma Stomach Neoplasms Internal medicine medicine Gastric mucosa Biomarkers Tumor Humans Receptor Survival rate Aged Neoplasm Staging Retrospective Studies Adiponectin receptor 1 Aged 80 and over Adiponectin business.industry Cancer General Medicine Middle Aged medicine.disease Prognosis Survival Rate medicine.anatomical_structure Endocrinology Oncology Gastric Mucosa Lymphatic Metastasis Cancer research Disease Progression Female Receptors Adiponectin business Follow-Up Studies |
| Zdroj: | Journal of cancer research and clinical oncology. 139(4) |
| ISSN: | 1432-1335 |
| Popis: | Adiponectin, an adipocyte-secreted endogenous insulin sensitizer, appears to play an important role in progression of several malignancies. Expression of adiponectin receptors—AdipoR1 and AdipoR2—has been documented in gastric cancer (GC) cell lines, but its role in GCs is still controversial. We investigated expression level of 2 adiponectin receptors and correlated their expression with prognosis in GC patients. We immunohistochemically evaluated AdipoR1 and AdipoR2 expression in 59 non-neoplastic gastric mucosas, 48 gastric adenomas, 250 GCs, and 58 lymph nodes involved by metastatic GC and assessed its association with clinicopathologic characteristics. Expression rates of both receptors increased stepwise in non-neoplastic gastric mucosa, gastric adenoma, intestinal-type GC, and metastatic GC (p |
| Databáze: | OpenAIRE |
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