Methodology for health risk assessment of combined exposures to multiple chemicals
| Autor: | Anna Beronius, Mirjam Luijten, Hilko van der Voet, Johanna Zilliacus, Annika Hanberg, Jacob D. van Klaveren |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Computer science
Toxicology Combined exposure Models Biological Risk Assessment Hazardous Substances 03 medical and health sciences Human health 0404 agricultural biotechnology Chemical mixtures Adverse outcome pathway Component (UML) Adverse Outcome Pathway Mixture Humans Computer Simulation 030304 developmental biology Risk assessment 0303 health sciences Toxicity data Health risk assessment 04 agricultural and veterinary sciences General Medicine Environmental exposure Environmental Exposure 040401 food science 3. Good health Biometris Risk analysis (engineering) Food Science |
| Zdroj: | Food and Chemical Toxicology 143 (2020) Food and Chemical Toxicology, 143 |
| ISSN: | 0278-6915 |
| Popis: | Focus on risks to human health and the environment from combined exposure to multiple chemicals ("mixture risk assessment") has increased in the last couple of decades. There has been a rise in awareness and concern in the community, especially concerning unintentional environmental exposure to unknown chemical mixtures. The Horizon 2020 project EuroMix has developed methodologies and tools for mixture risk assessment with a focus on component-based approach where substances are grouped based on toxicological considerations. Dose addition is used as the model for calculating the combined toxicity of mixture components. The methodology is anchored in the Adverse Outcome Pathway (AOP) concept, which provides a structured basis for e.g. grouping substances into assessment groups and identifying and collecting relevant toxicity data. The aim of this paper is to describes development of the methodology for mixture risk assessment and to provide detailed methodology for problem formulation, use of AOP networks for development of tiered testing strategies and grouping of substances, as well as considerations for use of dose addition methodology. |
| Databáze: | OpenAIRE |
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