5-Fluorouracil, 4-epidoxorubicin, and mitomycin C (FEM) combination chemotherapy for advanced gastric carcinoma. A phase-II trial by the 'chemotherapiegruppe gastrointestinaler tumoren (CGT)'
| Autor: | H. Flechtner, Lutz Edler, D. Fritze, M. Fritz, K. Kabelitz, H. Arnold, R. Herrmann, H. Henß, W. Queißer, M.E. Heim, F.A. Trux, H. Fritsch |
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| Rok vydání: | 1987 |
| Předmět: |
Oncology
Male Cancer Research medicine.medical_specialty Combination therapy Mitomycin Gastric carcinoma Mitomycins Stomach Neoplasms Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Neoplasm Metastasis Aged Epirubicin business.industry Mitomycin C Combination chemotherapy Hematology Advanced gastric cancer Middle Aged Combined Modality Therapy digestive system diseases Fluorouracil Doxorubicin Drug Evaluation Female Neoplasm Recurrence Local business medicine.drug |
| Zdroj: | Onkologie. 10(2) |
| ISSN: | 0378-584X |
| Popis: | In a phase-II-trial 40 patients with advanced gastric cancer were treated with 5-fluorouracil, 4-epidoxorubicin, mitomycin C (FEM) combination therapy. Twenty-five out of 30 patients with measurable disease were evaluable for response after 8 weeks of treatment. Seven patients achieved a partial remission (PR), suggesting a response rate of 28%. Ten patients had no change (NC) and 8 patients showed progression (P). The median time to progression for patients with PR was 7.2 months and for patients with NC 6.3 months. Median survival time for all patients was 5.3 months, for patients with PR and NC 9.9 months. WHO grade 3 toxicity appeared in 3% (WBC and nausea/vomiting) and 15% (alopecia) of patients. The data suggest that this regimen is not more active, but is better tolerated than the original FAM schedule. Therefore it seems suitable for out-patient treatment, for elderly patients and for those who cannot be treated by more aggressive drugs. |
| Databáze: | OpenAIRE |
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