Plasma levels of atazanavir and the risk of hyperbilirubinemia are predicted by the 3435C--T polymorphism at the multidrug resistance gene 1
| ISSN: | 1537-6591 |
|---|---|
| Přístupová URL adresa: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0b66a20ac7d69f624b6fedb80d63e0 https://pubmed.ncbi.nlm.nih.gov/16355344 |
| Rights: | OPEN |
| Přírůstkové číslo: | edsair.doi.dedup.....6b0b66a20ac7d69f624b6fedb80d63e0 |
| Autor: | Ana Rendón, Angélica Corral, Juan González-Lahoz, Sonia Rodríguez Novoa, Inmaculada Jiménez-Nácher, Pablo Barreiro, Ana Barrios, Vincent Soriano |
| Rok vydání: | 2005 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty Genotype Bilirubin Anti-HIV Agents Pyridines Atazanavir Sulfate HIV Infections Gastroenterology chemistry.chemical_compound Risk Factors Internal medicine Blood plasma medicine Odds Ratio Humans Genetic Predisposition to Disease Hyperbilirubinemia Polymorphism Genetic business.industry virus diseases Odds ratio Middle Aged Viral Load Multidrug Resistance Gene Atazanavir CD4 Lymphocyte Count Infectious Diseases chemistry Immunology HIV-1 RNA Viral Female Genes MDR business Viral load Oligopeptides medicine.drug |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 42(2) |
| ISSN: | 1537-6591 |
| Popis: | The 3435C-->T polymorphism at the multidrug resistance gene 1 (MDR1) was examined in 74 patients with human immunodeficiency virus who initiated atazanavir therapy. The MDR1 genotype distribution at position 3435 was 28% CC, 45% CT, and 27% TT. Plasma levels of atazanavir were significantly higher in patients with genotype CC than in those with CT or TT, and bilirubin levels correlated with atazanavir concentrations. |
| Databáze: | OpenAIRE |
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