Retrospective assessment of islet cell autoantibodies in pancreas organ donors
| Autor: | George W. Burke, Joseph M. Ferreira, Gloria Allende, Alberto Pugliese, Stavros Diamantopoulos, Gaetano Ciancio |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment Insulin Antibodies 030209 endocrinology & metabolism 030230 surgery Pancreas transplantation Gastroenterology ABO Blood-Group System 03 medical and health sciences Islets of Langerhans 0302 clinical medicine Pancreatectomy Internal medicine Diabetes mellitus Internal Medicine medicine Cadaver Humans Kidney transplantation Autoantibodies Retrospective Studies Advanced and Specialized Nursing Type 1 diabetes business.industry Glutamate Decarboxylase Autoantibody Clinical Care/Education/Nutrition/Psychosocial Research Immunosuppression medicine.disease Kidney Transplantation Tissue Donors 3. Good health medicine.anatomical_structure Diabetes Mellitus Type 1 Immunology Pancreas Transplantation Pancreas business |
| Zdroj: | Diabetes Care |
| ISSN: | 1935-5548 |
| Popis: | OBJECTIVE—Of deceased pancreas donors, 3–4% may have autoantibodies (AAb) to pancreatic islet cell antigens; these autoantibodies are well-established markers of type 1 diabetes. We investigated whether donor AAb positivity could affect the outcome of pancreas transplantation. RESEARCH DESIGN AND METHODS—We retrospectively tested AAb in 135 donors whose pancreata and kidneys were transplanted in type 1 diabetes patients. We measured AAb to glutamic acid decarboxylase (GAD-AAb), the tyrosine-phosphatase-like protein IA2 (IA2-AAb), and insulin (insulin-AAb). We then evaluated pancreas transplant outcome data. RESULTS—Four of 135 (2.96%) donors were AAb positive: three donors had GAD-AAb, and one donor had insulin-AAb. Their respective recipients became insulin independent on follow-up. Three of the four recipients had normal, insulin-producing grafts 3–5.8 years after transplant. The recipient of the insulin-AAb–positive donor pancreas developed chronic rejection following discontinuation of immunosuppression 3.3 years after transplant. CONCLUSIONS—Single AAb positivity did not affect the outcome of pancreas transplantation in our study. |
| Databáze: | OpenAIRE |
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