The genusErythrina L.: A review on its alkaloids, preclinical, and clinical studies
| Autor: | Renata Biegelmeyer, Douglas F. Rambo, Paulo Roberto Hrihorowitsch Moreno, Roger R. Dresch, Natally S.B. Toson, Amélia T. Henriques |
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| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
0303 health sciences biology Plant Extracts Stereochemistry Chemistry Alkaloid 030302 biochemistry & molecular biology Fabaceae Amaryllidaceae Morphinans biology.organism_classification 03 medical and health sciences Alkaloids 0302 clinical medicine Erythrinine Phytochemical Genus 030220 oncology & carcinogenesis Humans heterocyclic compounds Erythrina ALCALOIDES |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1099-1573 0951-418X |
| Popis: | Erythrina L. genus (Fabaceae) comprises about 115 species, and it has been extensively studied, mainly because of its alkaloids, which have pharmacological properties. References demonstrated that Erythrina spp. have a potential to act in the central nervous system, presenting anxiolytic and anticonvulsant properties already established. Phytochemical investigations confirmed the presence of tetracyclic alkaloids as the major compounds. However, other alkaloid classes have also been reported, including dimeric and trimeric substances, coupled through direct polymerization or two erythrinine units via an acetyl glucose. The present review covers the relevant literature from 1990 until 2017 and outlines the current data on chemical composition and preclinical and clinical studies on Erythrina species. Additionally, the quite striking analogy in the biosynthetic route of erythrin, morphinans, and Amaryllidaceae family alkaloids was also discussed. |
| Databáze: | OpenAIRE |
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