Actinotetraose L, a new tetrasaccharide derivative isolated from the mycelia of Amycolatopsis sp. HCa1
| Autor: | Zhi-Kai Guo, Ren-Xiang Tan, Wei Yan, Hui Ming Ge |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Pseudonocardiaceae
Stereochemistry T-Lymphocytes Hypercalciuria Pharmaceutical Science Oligosaccharides Amycolatopsis Grasshoppers Analytical Chemistry chemistry.chemical_compound Drug Discovery Actinomycetales Tetrasaccharide Animals Humans Cytotoxicity Nuclear Magnetic Resonance Biomolecular Mycelium Pharmacology biology Molecular Structure Organic Chemistry General Medicine biology.organism_classification Complementary and alternative medicine chemistry Molecular Medicine Methanol Two-dimensional nuclear magnetic resonance spectroscopy Derivative (chemistry) Immunosuppressive Agents |
| DOI: | 10.6084/m9.figshare.1495365.v1 |
| Popis: | A new tetrasaccharide derivative, actinotetraose L (1), was isolated from the methanol extract of the mycelia of the grasshopper-associated rare actinobacterium Amycolatopsis sp. HCa1. The structure of the new compound was elucidated by a combination of 1D, 2D NMR (HMQC, HMBC, COSY, and NOESY), and HR-ESI-MS analyses as O-{3,4-di-O-[(E)-2-ethyl-2-butenoyl]- β-D-glucopyranosyl-(1 → 2)}-O-{3,4-di-O-[(E)-2-methyl-2-butenoyl]-β-D-glucopyranosyl-(1 → 2)}-6,6-di-O-[(E)-2-methyl-2-butenoyl]-α-D-glucopyranosyl-(1 → 1)-α-D-glucopyranoside. The immunosuppressive activity and cytotoxicity of the compound were evaluated by T-cell viability and MTT assays. Nonetheless, no significant activity was observed. |
| Databáze: | OpenAIRE |
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