Cross-reactivity among fungal allergens: a clinically relevant phenomenon?
| Autor: | Sabine Zeller, Andreas G. Glaser, Reto Crameri, Monica Vilhelmsson, Claudio Rhyner |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Allergy Antigens Fungal In silico Dermatology Molecular cloning Cross Reactions medicine.disease_cause Cross-reactivity Microbiology Immune system Molecular genetics medicine Hypersensitivity Humans biology Fungi General Medicine Allergens Immunoglobulin E medicine.disease Asthma Infectious Diseases Immunology biology.protein Antibody Allergic bronchopulmonary aspergillosis |
| Zdroj: | Mycoses. 52(2) |
| ISSN: | 1439-0507 |
| Popis: | Summary Atopic patients suffering from allergic asthma, allergic rhinitis, or atopic eczema oftenhave detectable levels of serum IgE antibodies to fungi. Although the associationbetween fungal sensitisation and different forms of allergic diseases, including allergicasthma and life-threatening allergic bronchopulmonary aspergillosis, is wellestablished, the clinical relevance of cross-reactivity among different fungal speciesremains largely unknown. Recent progress in molecular cloning of fungal allergensand the availability of more than 40 completely sequenced fungal genomes facilitatescharacterisation, cloning, and production of highly pure recombinant allergens,identification of homologous and orthologous allergens widespread among the fungalkingdom, in silico prediction, and experimental in vitro and in vivo verification of cross-reactivity between homologous pan-allergens. These studies indicate that cross-reactivity is an important component of fungal sensitisation. Key words: Fungi, allergens, allergy, cross-reactivity, structure, clinical relevance. |
| Databáze: | OpenAIRE |
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