Generation of Stimulus Triggering From Intracortical Spike Activity for Brain–Machine–Body Interfaces (BMBIs)
| Autor: | Pedram Mohseni, Shahab Shahdoost, Randolph J. Nudo |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Nervous system
Engineering business.industry General Neuroscience 020208 electrical & electronic engineering 0206 medical engineering Rehabilitation Real-time computing Biomedical Engineering Stimulation 02 engineering and technology Stimulus (physiology) 020601 biomedical engineering Thresholding medicine.anatomical_structure Gate array Neuroplasticity 0202 electrical engineering electronic engineering information engineering Internal Medicine medicine Field-programmable gate array business Neuroscience Blanking |
| Zdroj: | IEEE Transactions on Neural Systems and Rehabilitation Engineering. 25:998-1008 |
| ISSN: | 1558-0210 1534-4320 |
| Popis: | Brain–machine–body interfaces (BMBIs) aim to create an artificial connection in the nervous system by converting neural activity recorded from one cortical region to electrical stimuli delivered to another cortical region, spinal cord, or muscles in real-time. In particular, conditioning-mode BMBIs utilize such activity-dependent stimulation strategies to induce functional re-organization in the nervous system and promote functional recovery after injury by exploiting mechanisms underlying neuroplasticity. This paper reports on reconfigurable, field-programmable gate array (FPGA)-based implementation of a translation algorithm to extract multichannel stimulus trigger signals from intracortical neural spike activity. The approach features digital spike discrimination based on user-set thresholding and time-amplitude windowing, decision making to support different triggering patterns for various stimulation scenarios, as well as trigger-pattern-dependent blanking schemes for robust operation in the presence of stimulus artifacts. Readily lending itself to low-power, low-area implementation for future integration, the algorithm has been synthesized on a Cyclone II FPGA using Altera’s Quartus II design software and validated experimentally with prerecorded intracortical neural spike activity from an anesthetized laboratory rat. |
| Databáze: | OpenAIRE |
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