Social behavior, neuroimmune markers and glutamic acid decarboxylase levels in a rat model of valproic acid-induced autism
| Autor: | Thet-Thet Lwin, Tin-Tin Win-Shwe, Ohn Mar, Motoki Imai, Nay Chi Nway, Hidehiro Watanabe |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Cell Adhesion Molecules Neuronal Glutamate decarboxylase Gene Expression Nerve Tissue Proteins Biology Toxicology Hippocampus Proinflammatory cytokine Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Neurodevelopmental disorder Neurotrophic factors Pregnancy Internal medicine medicine Hippocampus (mythology) Animals RNA Messenger Autistic Disorder Social Behavior 5-HT receptor Valproic Acid Behavior Animal Glutamate Decarboxylase Brain-Derived Neurotrophic Factor Membrane Proteins medicine.disease Disease Models Animal 030104 developmental biology Endocrinology Receptors Serotonin Autism Cytokines lipids (amino acids peptides and proteins) Female Inflammation Mediators 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | The Journal of toxicological sciences. 43(11) |
| ISSN: | 1880-3989 |
| Popis: | Autism is a complex neurodevelopmental disorder characterized by impaired social communication and social interactions, and repetitive behaviors. The etiology of autism remains unknown and its molecular basis is not yet well understood. Pregnant Sprague-Dawley (SD) rats were administered 600 mg/kg of valproic acid (VPA) by intraperitoneal injection on day 12.5 of gestation. Both 11- to 13-week-old male and female rat models of VPA-induced autism showed impaired sociability and impaired preference for social novelty as compared to the corresponding control SD rats. Significantly reduced mRNA expressions of social behavior-related genes, such as those encoding the serotonin receptor, brain-derived neurotrophic factor and neuroligin3, and significantly increased expression levels of proinflammatory cytokines, such as interleukin-1 β and tumor necrosis factor-α, were noted in the hippocampi of both male and female rats exposed to VPA in utero. The hippocampal expression level of gamma amino butyric acid (GABA) enzyme glutamic acid decarboxylase (GAD) 67 protein was reduced in both male and female VPA-exposed rats as compared to the corresponding control animals. Our results indicate that developmental exposure to VPA affects the social behavior in rats by modulating the expression levels of social behavior-related genes and inflammatory mediators accompanied with changes in GABA enzyme in the hippocampus. |
| Databáze: | OpenAIRE |
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