The significance of isolated Y chromosome loss in bone marrow metaphase cells from males over age 50 years
| Autor: | Jeanette E. Eckel-Passow, Anne E. Wiktor, Daniel L. Van Dyke, Janice M. Hodnefield, Curtis A. Hanson |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Pathology Myeloid Bone Marrow Cells Biology Y chromosome Bone Marrow medicine Humans Metaphase Aged Retrospective Studies Chromosomes Human Y Myelodysplastic syndromes Cytogenetics Karyotype Hematology Middle Aged medicine.disease Leukemia Myeloid Acute Leukemia medicine.anatomical_structure Oncology Karyotyping Myelodysplastic Syndromes Bone marrow Chromosome Deletion |
| Zdroj: | Leukemia Research. 35:1297-1300 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/j.leukres.2011.05.002 |
| Popis: | To further investigate the potential clinical significance of Y chromosome loss as the sole bone marrow karyotype change, we studied 161 Mayo Clinic male patients with 75% or more metaphase cells with Y loss, and correlated the percent Y loss with age and hematopathologic review. In patients with a lymphoproliferative or plasma cell disorder, the negligible proportion of bone marrow involvement cannot account for the observed high proportion of -Y cells. In males with myeloid disease, Y loss appears to often represent the abnormal myeloid clone, which may also harbor acquired genetic changes that are not observed by conventional cytogenetic analysis. |
| Databáze: | OpenAIRE |
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