Trajectories of BMI Before Diagnosis of Type 2 Diabetes: The Rotterdam Study
| Autor: | Eralda Asllanaj, Jana Nano, Abbas Dehghan, Eric J.G. Sijbrands, Taulant Muka, M. Arfan Ikram, Oscar H. Franco, Klodian Dhana |
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| Přispěvatelé: | Epidemiology, Internal Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Medicine (miscellaneous) 030209 endocrinology & metabolism 610 Medicine & health Type 2 diabetes Overweight Weight Gain Body Mass Index Cohort Studies 03 medical and health sciences Rotterdam Study 0302 clinical medicine Endocrinology Insulin resistance SDG 3 - Good Health and Well-being Weight loss Risk Factors 360 Social problems & social services Internal medicine Diabetes mellitus Weight Loss medicine Humans 030212 general & internal medicine Obesity Aged Netherlands Nutrition and Dietetics business.industry Epidemiology/Genetics Original Articles Middle Aged medicine.disease Diabetes Mellitus Type 2 Latent Class Analysis Female Original Article medicine.symptom business Body mass index |
| Zdroj: | Nano, Jana; Dhana, Klodian; Asllanaj, Eralda; Sijbrands, Eric; Ikram, M Arfan; Dehghan, Abbas; Muka, Taulant; Franco, Oscar H. (2020). Trajectories of BMI Before Diagnosis of Type 2 Diabetes: The Rotterdam Study. Obesity, 28(6), pp. 1149-1156. Wiley 10.1002/oby.22802 Obesity (Silver Spring, Md.) Obesity 28, 1149-1156 (2020) Obesity, 28(6), 1149-1156. Wiley-Blackwell |
| ISSN: | 1930-7381 |
| Popis: | Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society (TOS) Objective: People with diabetes show great variability in weight gain and duration of obesity at the time of diagnosis. BMI trajectories and other cardiometabolic risk factors prior to type 2 diabetes were investigated. Methods: A total of 6,223 participants from the Rotterdam Study cohort were included. BMI patterns before diagnosis of diabetes were identified through latent class trajectories. Results: During a mean follow-up of 13.7 years, 565 participants developed type 2 diabetes. Three distinct trajectories of BMIwere identified, including the “progressive overweight” group (n = 481, 85.1%), “progressive weight loss” group (n = 59, 10.4%), and “persistently high BMI” group (n = 25, 4.4%). The majority, the progressive overweight group, was characterized by a steady increase of BMI in the overweight range 10 years before diabetes diagnosis. The progressive weight lossgroup had fluctuations of glucose and marked beta cell function loss. The persistently high BMI group was characterized by a slight increase in insulin levels and sharp increase of insulin resistance accompanied by a rapid decrease of beta cell function. Conclusions : Heterogeneity of BMI changes prior to type 2 diabetes was found in a middle-aged and elderly white population. Prevention strategies should be tailored rather than focusing only on high-risk individuals. |
| Databáze: | OpenAIRE |
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