Anti-Inflammatory Compounds from Vietnamese Piper bavinum
| Autor: | Minh Thu Doan, Huu Tung Nguyen, Byung Sun Min, Manh Hung Tran, Dao Cuong To, Viet Dung Hoang, Nhu Tuan Huynh, Phi Hung Nguyen |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Piper bavinum
biology Article Subject 010405 organic chemistry medicine.drug_class Chemistry General Chemistry Fractionation Piperaceae biology.organism_classification 01 natural sciences In vitro Anti-inflammatory 0104 chemical sciences 010404 medicinal & biomolecular chemistry Biochemistry medicine Macrophage No production QD1-999 IC50 |
| Zdroj: | Journal of Chemistry, Vol 2020 (2020) |
| ISSN: | 2090-9063 |
| DOI: | 10.1155/2020/1038636 |
| Popis: | This study reports the anti-inflammatory activity-guided fractionation of the aerial part of Piper bavinum C. CD. (Piperaceae) that led to the isolation of eight secondary metabolites (1–8). The chemical structures of 1–8 were established mainly by NMR and mass spectra. Compound 5 was isolated from P. bavinum for the first time. All the isolated compounds were evaluated against LPS-induced NO production in macrophage RAW 264.7 cells in vitro. Among them, compound 4 showed the most potent inhibitory activity against the LPS-induced NO production with an IC50 value of 5.2 μM followed by compound 5 that inhibited NO production with an IC50 value of 13.5 μM. In the protein levels, compound 4 suppressed LPS-induced COX-2 and iNOS expressions in a dose-dependent manner. The results suggested that P. bavinum and its constituents might exert anti-inflammatory effects. |
| Databáze: | OpenAIRE |
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