In-hospital prognostic role of coronary atherosclerotic burden in COVID-19 patients
| Autor: | Pier Pasquale Leone, Matteo Maurina, Fabio Fazzari, Alexia Rossi, Renato Bragato, Eleonora Indolfi, Valeria Donghi, Lorenzo Monti, Arturo Chiti, Ottavia Cozzi, Mirko Curzi, Francesco Cannata, Giulio G. Stefanini |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Population Coronary Artery Disease Coronary artery disease Interquartile range Predictive Value of Tests Internal medicine Clinical endpoint Medicine Humans cardiovascular diseases Hospital Mortality Risk factor education Vascular Calcification Retrospective Studies education.field_of_study business.industry SARS-CoV-2 Mortality rate nutritional and metabolic diseases COVID-19 Retrospective cohort study General Medicine Middle Aged medicine.disease Prognosis Coronary Vessels Hospitalization Italy Heart Disease Risk Factors Predictive value of tests Female Cardiology and Cardiovascular Medicine business Tomography X-Ray Computed |
| Zdroj: | Journal of cardiovascular medicine (Hagerstown, Md.). 22(11) |
| ISSN: | 1558-2035 |
| Popis: | AIMS: Currently, there are few available data regarding a possible role for subclinical atherosclerosis as a risk factor for mortality in Coronavirus Disease 19 (COVID-19) patients. We used coronary artery calcium (CAC) score derived from chest computed tomography (CT) scan to assess the in-hospital prognostic role of CAC in patients affected by COVID-19 pneumonia. METHODS: Electronic medical records of patients with confirmed diagnosis of COVID-19 were retrospectively reviewed. Patients with known coronary artery disease (CAD) were excluded. A CAC score was calculated for each patient and was used to categorize them into one of four groups: 0, 1-299, 300-999 and at least 1000. The primary endpoint was in-hospital mortality for any cause. RESULTS: The final population consisted of 282 patients. Fifty-seven patients (20%) died over a follow-up time of 40 days. The presence of CAC was detected in 144 patients (51%). Higher CAC score values were observed in nonsurvivors [median: 87, interquartile range (IQR): 0.0-836] compared with survivors (median: 0, IQR: 0.0-136). The mortality rate in patients with a CAC score of at least 1000 was significantly higher than in patients without coronary calcifications (50 vs. 11%) and CAC score 1-299 (50 vs. 23%), Pâ |
| Databáze: | OpenAIRE |
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