The Frequency of Double Expresser in Selected Cases of High Grade Diffuse Large B-Cell Lymphomas
| Autor: | Maria Naseem, Muhammad Tahir Khadim, Muhammad Asif, Hafeez Ud-Din, Iman Shoaib, Shahid Jamal |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Poor prognosis Gastroenterology Translocation Genetic Proto-Oncogene Proteins c-myc 03 medical and health sciences 0302 clinical medicine Internal medicine Biomarkers Tumor medicine Humans Lymph node B cell Gene Rearrangement business.industry Primary sites General Medicine Middle Aged Gene Expression Regulation Neoplastic Survival Rate Immunohistochemistry (IHC) 030104 developmental biology medicine.anatomical_structure Proto-Oncogene Proteins c-bcl-2 R-CHOP CERVICAL LYMPH NODE ENLARGEMENT 030220 oncology & carcinogenesis Concomitant Proto-Oncogene Proteins c-bcl-6 Immunohistochemistry Female Lymphoma Large B-Cell Diffuse Diffuse Large B Cell Lymphoma (DLBCL) Neoplasm Grading Double expresser (DEL) business Median survival Research Article Follow-Up Studies |
| Zdroj: | Asian Pacific Journal of Cancer Prevention : APJCP |
| ISSN: | 2476-762X |
| DOI: | 10.31557/apjcp.2020.21.4.1103 |
| Popis: | Background Diffuse large B-cell lymphomas (DLBCL) are fast-growing non-Hodgkin lymphomas that affect B-lymphocytes. Double expressor DLBCL is the concomitant expression of Myc and Bcl-2 proteins during lymphomas which results in poor prognosis of patients. This study aimed to determine the frequency of double expresser in high grade diffuse large B-cell lymphomas. Materials and methods The study was conducted on 74 cases (54 males (68.4%) and 20 females (25.3%)) of DLBCL between August 2018 to January 2019. The mean age of the 74 patients was 51.7 years + 18.5. Expression of proteins c-Myc, Bcl-2 and Bcl-6 were evaluated by immunohistochemistry. The involvement of primary lymph node was reported in 38 cases (51.3%) whereas, extra nodal site was observed in 22 cases (29.7%). Among the primary sites, the cervical lymph node enlargement was the most frequent site of presentation. Results The rearrangement pattern was studied among 74 patients, 35 (47%) were found to have either one of the rearrangements i.e. Myc, Bcl-2, or Bcl-6. On the other hand, 14 (18.9%) had shown double rearrangements i.e. Bcl-2 and c-Myc (11 cases) and Bcl-6 and c-Myc (3 cases). The Bcl-2 and Bcl-6 rearrangements were demonstrated by 12 cases whereas 2 cases (2.7%) indicated all three types of rearrangements i.e. c-Myc, Bcl-2, and Bcl-6. In 11 cases the Bcl-2 and c-Myc rearrangements were found to be Bcl-2 > 50% and c-Myc > 40% and demonstrating the overall frequency of double expressers as 14.8%. The prognosis of the mentioned cases was extremely poor, median survival of 10 months. Conclusion The concurrent expression of Bcl-2 and c-Myc was found to be 14% (level of expression for Bcl-2 > 50% and c-Myc > 40%) which is potentially a significant health burden and an emerging threat. |
| Databáze: | OpenAIRE |
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