Hematogone Hyperplasia in Copper Deficiency
| Autor: | Weina Chen, Lisa M. Sutton, Madhuri Vusirikala |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Myeloid Anemia Bone Marrow Cells Biology Neutropenia Diagnosis Differential hemic and lymphatic diseases medicine Humans Cytopenia Hyperplasia Cytogenetics Anatomical pathology General Medicine Middle Aged medicine.disease Hematologic Diseases medicine.anatomical_structure Myelodysplastic Syndromes Copper deficiency Copper |
| Zdroj: | American Journal of Clinical Pathology. 132:191-199 |
| ISSN: | 1943-7722 0002-9173 |
| Popis: | Copper deficiency is likely an underrecognized cause of anemia and neutropenia and may masquerade as a myelodysplastic syndrome (MDS). We report 2 cases of copper deficiency in which the diagnosis was suggested based on the characteristic morphologic findings, such as cytoplasmic vacuolization of erythroid and myeloid precursors and iron-containing plasma cells. It is interesting that both patients had hematogone hyperplasia. This phenomenon, largely absent in MDS, may aid in distinguishing nonclonal causes of cytopenias, such as copper deficiency, from MDS. It is of crucial importance to identify treatable causes of cytopenias when MDS is suspected. We recommend copper level assessment in patients suspected of having low-grade MDS, especially patients with neuropathy and normal results of cytogenetic studies. |
| Databáze: | OpenAIRE |
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