The role of methyl-binding proteins in chromatin organization and epigenome maintenance
| Autor: | Nobuhiro Sasai, Pierre-Antoine Defossez, Mitsuyoshi Nakao, Alexandra Fournier |
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| Rok vydání: | 2011 |
| Předmět: |
Computational biology
Biology Biochemistry DNA-binding protein Epigenesis Genetic chemistry.chemical_compound Genetics Epigenome editing Animals Humans Molecular Biology Epigenomics Binding Sites Genome DNA General Medicine Epigenome DNA Methylation Chromatin DNA-Binding Proteins chemistry DNA methylation CpG Islands Heterochromatin protein 1 |
| Zdroj: | Briefings in Functional Genomics. 11:251-264 |
| ISSN: | 2041-2657 2041-2649 |
| DOI: | 10.1093/bfgp/elr040 |
| Popis: | Methylated DNA can be specifically recognized by a set of proteins called methyl-CpG-binding proteins (MBPs), which belong to three different structural families in mammals: the MBD family, the Kaiso and Kaiso-like proteins and the SRA domain proteins. A current view is that, once bound to methylated DNA, MBPs translate the DNA methylation signal into appropriate functional states, through interactions with diverse partners. However, if some of the biological functions of MBPs have been widely described--notably transcriptional repression--others are poorly understood, and more generally the extent of MBP activities remains unclear. Here we propose to discuss the role of MBPs in two crucial nuclear events: chromatin organization and epigenome maintenance. Finally, important challenges for future research as well as for biomedical applications in pathologies such as cancers--in which DNA methylation patterns are widely altered--will be mentioned. |
| Databáze: | OpenAIRE |
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