The Role of Plasma Calprotectin in Non-infectious Uveitis
| Autor: | Elena Grau García, José Andrés Román Ivorra, Lucía Martínez Costa Pérez, Mara Albert Fort, Elia Valls Pascual, Juan José Alegre Sancho, José María López Ortega, Antonio Hernández Pons |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Aging Visual Acuity Slit Lamp Microscopy Gastroenterology Uveitis 03 medical and health sciences Cellular and Molecular Neuroscience Infectious uveitis fluids and secretions 0302 clinical medicine Internal medicine Medicine Humans Prospective Studies Fluorescein Angiography Prospective cohort study Aged business.industry Middle Aged medicine.disease Sensory Systems Ophthalmology Cross-Sectional Studies 030221 ophthalmology & optometry Observational study Female Calprotectin business Leukocyte L1 Antigen Complex 030217 neurology & neurosurgery Biomarkers Tomography Optical Coherence |
| Zdroj: | Current eye research. 46(8) |
| ISSN: | 1460-2202 |
| Popis: | To investigate the role of plasma calprotectin in non-infectious uveitis.This is an observational both cross-sectional and prospective study. Patients with active non-infectious uveitis were recruited as well as nonuveitic controls. Plasma calprotectin was determined and an ophthalmological examination was performed for both patients and controls. Independent variables possibly influencing levels of plasma calprotectin were recorded and analyzed. Categorical variables were compared by chi-square test (applying correction by continuity if necessary). T-test (or Kruskal-Wallis when appropriate) was used to compare averages. Multiple linear regression analysis was used to assess relationship between plasma calprotectin levels and independent variables. Spearman coefficient was calculated in order to establish correlation between plasma calprotectin and anterior chamber cell grading. Changes in plasma calprotectin levels between the flare beginning and its resolution were determined with mixed model for repeated measures. R software (version 3.6.0) was used to perform the statistical analysis.We included 74 patients and 40 controls in the cross-sectional study. Plasma calprotectin levels were higher in uveitis patients compared to those of controls (Plasma calprotectin levels are elevated in uveitis patients and are influenced by age and anatomical location of uveitis. Further investigation is needed to assess the relationship between calprotectin and uveitis activity. |
| Databáze: | OpenAIRE |
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