MRI in children receiving total parenteral nutrition
| Autor: | G. Quaghebeur, P. J. Milla, W. J. Taylor, A. P. Reynolds, J. Fell, D. P. E. Kingsley |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Pathology Neurology Encephalopathy chemistry.chemical_element Manganese Gastroenterology Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Child Whole blood Neuroradiology medicine.diagnostic_test business.industry Nutritional Requirements Brain Infant Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Parenteral nutrition chemistry Child Preschool Female Parenteral Nutrition Total Neurology (clinical) Abnormality Cardiology and Cardiovascular Medicine business |
| Zdroj: | Neuroradiology. 38:680-683 |
| ISSN: | 1432-1920 0028-3940 |
| DOI: | 10.1007/s002340050333 |
| Popis: | Cranial MRI was obtained in 13 of a group of 57 children receiving long-term parenteral nutrition, who were being investigated for hypermanganasaemia. Increased signal intensity on T1-weighted images has been reported in adult patients on long-term parenteral nutrition and with encephalopathy following chronic manganese exposure in are welding. It has been postulated that these changes are due to deposition of the paramagnetic trace element manganese. In excess manganese is hepato- and neurotoxic and we present the correlation of whole blood manganese levels with imaging findings. The age range of our patients was 6 months to 10 years, and the duration of therapy 3 months to 10 years. In 7 children we found characteristic increased signal intensity on T1-weighted images, with no abnormality on T2-weighted images. All patients had elevated whole blood manganese levels, suggesting that the basis for this abnormality is indeed deposition of manganese within the tissues. |
| Databáze: | OpenAIRE |
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