Characterization and behavior of composite hydrogel prepared from bamboo shoot cellulose and β-cyclodextrin
| Autor: | Wenchao Luo, Huihua Huang, Shumin Liu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Beta-Cyclodextrins
02 engineering and technology 010402 general chemistry 01 natural sciences Biochemistry Hydrogel Polyethylene Glycol Dimethacrylate chemistry.chemical_compound Structural Biology Polymer chemistry Spectroscopy Fourier Transform Infrared medicine Humans Epichlorohydrin Cellulose Fourier transform infrared spectroscopy Molecular Biology Drug Carriers beta-Cyclodextrins technology industry and agriculture General Medicine 021001 nanoscience & nanotechnology 0104 chemical sciences Carboxymethyl cellulose Drug Liberation chemistry Ionic strength Swelling medicine.symptom 0210 nano-technology Drug carrier Sasa Plant Shoots Nuclear chemistry medicine.drug |
| Zdroj: | International journal of biological macromolecules. 89 |
| ISSN: | 1879-0003 |
| Popis: | Carboxymethyl cellulose was derived from bamboo shoot cellulose via chemical modification and was prepared into composite hydrogels by cross-linkage with β-cyclodextrin using epichlorohydrin as crossing agent. The structure of the prepared hydrogel was characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis and scanning electron microscopy. The results showed that the prepared composite hydrogel was sensitive to surrounding changes in pH value, temperature and ionic strength. Under the surroundings of low temperatures and high pH values, the prepared hydrogel had significant high swelling ratios (23338±988% at 15°C and 6937±112% at pH 8.0, respectively). In the solution of 0.1mol/L NaCl, the hydrogel showed the maximum water retention rate (48.73%). Sodium salicylate was used as the model drug to study the behaviors of hydrogel adsorption and release in simulated intestinal (at pH 7.4) and gastric liquid (at pH 1.8) surroundings. The prepared composite hydrogel exhibited higher drug release ratio in simulated intestinal liquid (63.09% after 380min) than in gastric liquid (22.09% after 400min). These pH responses of the prepared composite hydrogel showed its potential applications, especially as the drug carrier to attain control release of drugs under different surrounding conditions or organs in human body. |
| Databáze: | OpenAIRE |
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