Intravenous doxapram administration as a potential model of panic attacks in rats
| Autor: | Jadna Bogado Lopes, Andrea Siqueira Haibara, Luara A. Batista, Rayssa C Brianis, Fabrício A. Moreira |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.drug_class Periaqueductal gray 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Medicine Animals Periaqueductal Gray Rats Wistar Maze Learning Pharmacology Benzodiazepine Alprazolam business.industry Panic disorder Panic Doxapram URB597 medicine.disease 030227 psychiatry Rats Psychiatry and Mental health Disease Models Animal Analeptic chemistry Anesthesia Benzamides Panic Disorder Administration Intravenous Central Nervous System Stimulants Carbamates medicine.symptom business Proto-Oncogene Proteins c-fos 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Behavioural pharmacology. 32(3) |
| ISSN: | 1473-5849 |
| Popis: | Panic disorder can be categorized into the nonrespiratory or the respiratory subtypes, the latter comprising dyspnea, shortness of breath, chest pain, feelings of suffocation, and paresthesias. Doxapram is an analeptic capable of inducing panic attacks with respiratory symptoms in individuals diagnosed with the disorder; however, its neuroanatomical targets and its effects on experimental animals remain uncharacterized. One of the brain regions proposed to trigger panic attacks is the midbrain periaqueductal gray (PAG). Therefore, in this study, we evaluated the effects of doxapram in Fos (c-Fos) protein expression in the PAG and characterized its cardiorespiratory and behavioral effects on the elevated T maze and in the conditioned place aversion (CPA) paradigms. Doxapram increased Fos expression in different columns of the PAG, increased respiratory frequency, decreased heart rate, and increased arterial pressure when injected via intravenous route. Alprazolam, a panicolytic benzodiazepine, injected via intraperitoneal route, decreased respiratory frequency, whereas URB597, an anandamide hydrolysis inhibitor injected via intraperitoneal route, was ineffective. Doxapram injected via intraperitoneal route induced an anxiogenic-like effect in the elevated T-maze model; however, it failed to induce CPA. This study suggests that the cardiorespiratory and behavioral effects of doxapram in rodents serve as an experimental model that can provide insights into the neurobiology of panic attacks. |
| Databáze: | OpenAIRE |
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