Discovery of new chemical leads for selective EP1 receptor antagonists

Autor:	Maki Iwahashi, Shuichi Ohuchida, Michiyoshi Kobayashi, Yuuki Nagao, Masaaki Toda, Atsushi Naganawa, Masatoshi Koketsu, Hiromu Egashira, Tetsuji Saito, Kigen Kondo, Tohru Kambe, Hiroshi Yamamoto, Takayuki Maruyama, Hisao Nakai
Rok vydání:	2006
Předmět:	Stereochemistry Carboxylic acid Clinical Biochemistry Pharmaceutical Science CHO Cells Benzoates Biochemistry Chemical synthesis Receptor subtype Structure-Activity Relationship Cricetinae Drug Discovery Animals Receptors Prostaglandin E Receptor Molecular Biology Alkyl chemistry.chemical_classification Analgesics Sulfonamides Binding Sites Organic Chemistry Receptors Prostaglandin E EP1 Subtype Sulfonamide chemistry Molecular Medicine lipids (amino acids peptides and proteins) Selectivity
Zdroj:	Bioorganic & Medicinal Chemistry. 14:5562-5577
ISSN:	0968-0896
DOI:	10.1016/j.bmc.2006.04.038
Popis:	A series of 4-({2-[alkyl(phenylsulfonyl)amino]phenoxy}methyl)benzoic acids were identified as functional PGE 2 antagonists with selectivity for the EP1 receptor subtype starting from a chemical lead 1 , which was found while screening our in-house compound library. Discovery of the optimized analogs 21 – 23 is presented here and structure–activity relationships (SAR) are also discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6afb5c5cb186828ec1438a7001512c32 https://doi.org/10.1016/j.bmc.2006.04.038 Zobrazit plný text záznamu Full Text from ScienceDirect