A retrospective study on chemical and radioactive synovectomy in severe haemophilia patients with recurrent haemarthrosis
| Autor: | N. Ounnoughène, P. Verrier, Y. Sultan, D. Vassilieff, P. Molho, C.-J. Menkes, J.-M. Schacher, N. Stieltjes |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
medicine.medical_specialty Triamcinolone acetonide Adolescent Osmium Tetroxide medicine.medical_treatment Synovectomy Hemophilia A Haemophilia Injections Intra-Articular Von willebrand Recurrence Hemarthrosis medicine Humans Yttrium Radioisotopes In patient Child Genetics (clinical) Retrospective Studies Radioisotopes Haemophilic arthropathy business.industry Retrospective cohort study Hematology General Medicine Middle Aged medicine.disease Surgery Child Preschool Radiological weapon Radiopharmaceuticals business medicine.drug |
| Zdroj: | Haemophilia. 5:115-123 |
| ISSN: | 1365-2516 1351-8216 |
| DOI: | 10.1046/j.1365-2516.1999.00287.x |
| Popis: | Between 1970 and 1994, 116 chemical and 90 radioactive synovectomies were performed in 107 patients with severe haemophilia and two with type 3 von Willebrand's disease. The products used were osmic acid (OA) in 100 cases, 90-Yttrium in 35 cases, 186-Rhenium in 48, 169-Erbium in two, hexacetonide triamcinolone in 16 and radioactive gold in five cases. The use of radioactive colloids is not allowed in France in patients under 15 years of age. Twenty-nine patients had more than one synovectomy per joint. All patients were evaluated for 6 months post-synovectomy, using both a clinical and a radiological score. Six months after synovectomy, a good or excellent result was obtained for 81% of the joints treated with isotopes, compared with 44% of those treated with OA, P < 0.001. This superiority of isotopes over osmic acid was still observed after 6 months for the 89 joints that were re-evaluated, with follow-up ranging from 1 to 9 years. It was possible to calculate a radiological score in 84 cases. With OA the best results were from the joints with the lowest scores pre-synovectomy ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|