A fluorogenic probe targeting two spatially separated enzymes for selective imaging of cancer cells

Autor:	Sang-Hyun Park, Hyoje Jung, Yujun Kim, Injae Shin
Rok vydání:	2022
Předmět:	Diagnostic Imaging Neoplasms Materials Chemistry Metals and Alloys Ceramics and Composites General Chemistry Catalysis Histone Deacetylases Surfaces Coatings and Films Electronic Optical and Magnetic Materials Fluorescent Dyes
Zdroj:	Chemical communications (Cambridge, England). 58(25)
ISSN:	1364-548X
Popis:	We describe a fluorogenic probe BocLys(Ac)-AB-FC targeting both histone deacetylases (HDACs) and cathepsin L, which are overexpressed in spatially separated subcellular organelles of cancer cells. The results show that this fluorogenic probe can be used for selective cancer cell imaging without interference arising from normal cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af90722bb52c91d8b57507c7ef682e9 https://pubmed.ncbi.nlm.nih.gov/35266486 Zobrazit plný text záznamu