Modification of X-ray Survival Curves of Stem-cells by Different Doses of Erythropoietin
| Autor: | L. G. Lajtha, K. Hirashima, S. C. Tso, D. D. Porteous |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
medicine.medical_specialty
Polycythemia Biology Mice hemic and lymphatic diseases Internal medicine medicine Animals Blood Transfusion Erythropoiesis Citrates Radiometry Erythropoietin Survival analysis Multidisciplinary X-ray Erythrocyte Aging Iron Isotopes Radiation effect Radiation Injuries Experimental Endocrinology Immunology Stem cell Injections Intraperitoneal medicine.drug |
| Zdroj: | Nature. 206:204-206 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/206204b0 |
| Popis: | A PREVIOUS study of stem-cell response to erythropoietin in the polycythaemic mouse after 150 rads showed an initial depression to values between 5 and 15 per cent of unirradiated controls1. Gurney2, however, in an earlier publication, reported an erythropoietin response after a single dose of 150 rads of about 30–40 per cent of control. The experiments were similar except for the dose of erythropoietin used: in our experiments about 0.5 unit (M.R.C. Standard ‘A’)3 and in Gurney's 6 units Armour Company erythropoietin (≍ 10 units M.R.C. Standard ‘A’). We therefore decided to investigate whether or not the dose of erythropoietin influences the apparent radiation effect in this system. |
| Databáze: | OpenAIRE |
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