Circumvention of chemotherapy-induced myelosuppression by transfer of the mdr1 gene
| Autor: | Dinko Valerio, Kees Nooter, Jan J.B. Boesen |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Oncology
medicine.medical_specialty Genetic enhancement medicine.medical_treatment Drug Resistance Antineoplastic Agents Drug resistance Bone Marrow Internal medicine medicine Animals Humans ATP Binding Cassette Transporter Subfamily B Member 1 Pharmacology Chemotherapy Hematology Membrane Glycoproteins Myeloproliferative Disorders business.industry Gene Transfer Techniques Cancer Genetic Therapy medicine.disease Hematopoietic Stem Cells Haematopoiesis medicine.anatomical_structure Immunology Bone marrow Stem cell business Carrier Proteins |
| Zdroj: | Biotherapy (Dordrecht, Netherlands). 6(4) |
| ISSN: | 0921-299X |
| Popis: | Drug-induced myelosuppression is a frequent reason for curtailing chemotherapy in cancer patients. 'Rescue' of myelosuppressed patients with autologous marrow transplants is reasonably advanced and permits an increase in the dose of anticancer drugs. Despite this improvement, patients often relapse with drug resistance disease. The human multidrug resistance (mdr1) gene might make it possible to render hemopoietic stem cells resistant to anticancer drugs after transfer of this gene. By introducing resistant stem cells into patients it might be possible to treat these patients repeatedly with otherwise ablative therapy. This review explores the feasibility of mdr1 gene therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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