Diagnostic Value of Semiquantitative Analysis of 99mTechnetium-Methoxyisobutylisonitrile (99mTc-MIBI Imaging in Predicting Early-Stage Cervical Lymph Node Metastasis of Thyroid Carcinoma
| Autor: | Xiao-Chun Zhu, Kai Zhou, Yu-Bo Ma, Shi-Qing Xu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Technetium Tc 99m Sestamibi Pathology medicine.medical_specialty Logistic regression 030218 nuclear medicine & medical imaging Metastasis Thyroid carcinoma Lesion 03 medical and health sciences 0302 clinical medicine Clinical Research Predictive Value of Tests Diagnosis Medicine Humans Thyroid Neoplasms ATP Binding Cassette Transporter Subfamily B Member 1 Stage (cooking) Radionuclide Imaging Pathological Aged Receiver operating characteristic business.industry P-Glycoprotein General Medicine Middle Aged medicine.disease Prognosis 030220 oncology & carcinogenesis Lymphatic Metastasis Immunohistochemistry Female Lymph Nodes medicine.symptom Radiopharmaceuticals business Nuclear medicine |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 1234-1010 |
| Popis: | BACKGROUND The aim of this study was to evaluate the value of semiquantitative analysis (SQA) of 99mTc-MIBI imaging in predicting early-stage cervical lymph node metastasis (CLNM) in thyroid carcinoma (TC). MATERIAL AND METHODS TC patients (n =106) undergoing surgical resection and histopathological examination were enrolled. All patients received 99mTc-MIBI imaging prior to surgery. P-glycoprotein (P-gp) expression was detected by PT-PCR and immunohistochemistry. With pathological results as the criterion standard, the diagnostic efficiency of 99mTc-MIBI imaging in predicting early-stage CLNM was evaluated. The correlation of P-gp with 99mTc-MIBI imaging was investigated. Logistic regression analysis was applied for analyzing the factors affecting early-stage CLNM. RESULTS The detection rate and misdiagnosis rate of 99mTc-MIBI imaging for early-stage CLNM diagnosis were 87.3% and 12.7%, respectively. Receiver operating characteristic (ROC) curve analysis showed an accuracy of 99mTc-MIBI imaging of 85.85%. Preoperative 99mTc-MIBI scan showed statistical differences between metastasis and non-metastasis groups in early and delayed T/NT and washout rate (all P |
| Databáze: | OpenAIRE |
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